Amphiphilic structures are likely to self-assemble, partially due to the microsegregation effect [1]. The shape of these amphiphilic molecules determines the resulting phases and structures [2]. Cellular membranes are actually made of self-assembling molecules, such as artificial structures like micelles and liposomes, amongst others.
Porphyrins substituted with lipidic moieties form nanostructures that have been named porphysomes [3]. They have been successfully used in photomedicine, thanks to their photodynamic and photothermal properties.Phthalocyanines, with the maximum absorbance centred at 700 nm [4], are considered as remarkable photosensitising cores for photodynamic applications [5].
In an attempt to form phthalocyanine-based photoactive nanostructures, amphiphilic phthalocyanines have been designed and are being synthesized. Our current progresses towards this end will be presented.

Acknowledgements: The Scientific and Technological Research Council of Turkey (TUBITAK) and the French Embassy in Turkey are gratefully acknowledged for the bilateral Parteneriat Hubert Curien between Turkey and France (project Bosphorus 119R052 / 44754NA).

[1] C. Tschierske, J. Mater. Chem., 2001, 11, 2647-2671
[2] F. Dumoulin, D. Lafont, T.-L. Huynh, P. Boullanger, G. Mackenzie, J. J. West, and John W. Goodby, Chem. Eur. J., 2007, 13, 5585-5600.
[3] J. F. Lovell, Ch. S. Jin, E. Huynh, H. Jin, C. Kim, J. L. Rubinstein, W. C. W. Chan, W. Cao, L. V. Wang & G. Zheng, Nature Materials, 2011, 10, 324-332
[4] S. Z. Topal, U. Isci, U. Kumru, D. Atilla, A. G. Gürek, C. Hirel, M. Durmus, J.-B. Tommasino, D. Luneau, S. Berber, F. Dumoulin and V. Ahsen, Dalton Trans. 2014, 43, 6897-6908
[5] P.-C. Lo, M. S. Rodriguez-Morgade, D. K. P. Ng, T. Torres, R. Pandey and F. Dumoulin, Chemical Society Reviews, 2020, 49, 1041-1056

Véronique Rosilio

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